La Folie, Quo Vadis, Evo-Devo?

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Many methods of ortholog inference have been proposed, and their comparative performance has been reviewed.

These methods belong to the two major classes of approaches:

1. identify all homologs in a set of species and then attempt to distinguish between orthologs and paralogs by analyzing the distribution of the genes from different species
across the tips of the tree

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GraphWeb is a public web server for graph-based analysis of biological networks that:

analyses directed and undirected, weighted and unweighted
heterogeneous networks of genes, proteins and microarray probesets for

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an integrated system for functional investigation of microRNAs

http://mirgator.kobic.re.kr:8080/MEXWebApp/

miRGator v2.0 is an integrated database of microRNA-associated gene expression database, which aims to facilitate functional investigation of microRNAs.
The miRGator v2.0 contains information about :

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Detecting Sequence Polymorphisms Associated with Meiotic Recombination Hotspots

LDsplit is a novel computational approach for detecting association of recombination hotspots with genetic polymorphisms.

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ProPhylER

http://www.prophyler.org/index.html

ProPhylER provides predictive evolutionary analyses of eukaryotic proteins.

ProPhylER puts comprehensive constraint data on tens of thousands of
eukaryotic proteins, represented by hundreds of thousands of individual

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http://probcons.stanford.edu/

PROBCONS is an efficient protein multiple sequence alignment program,

which has demonstrated a statistically significant improvement in accuracy compared
to several leading alignment tools.

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http://www.compbio.dundee.ac.uk/www-pips/

http://mint.bio.uniroma2.it/mint/Welcome.do

http://www.hprd.org/

Database ofInteractingProteins

http://dip.doe-mbi.ucla.edu/dip/Main.cgi

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