La Folie, Quo Vadis, Evo-Devo?

http://www.nature.com/nrg/journal/v10/n1/full/nrg2510.html

Thermodynamic models of gene expression:

Assumption ~ the level of gene expression is proportional to the equilibrium probability that RNA polymerase is bound to the promoter of interest

Shortage ~ over-fitting owing to the small number of genomic promoters that have been studied in eukaryotic systems

Solution ~ synthetic gene promoters

Scientists ~ Cohen and colleagues

Model organism ~ Saccharomyces cerevisiae

Application ~ predict novel transcription factor–gene interactions

Assumption 2 ~ gene regulation is completely controlled by simple DNA–protein and protein–protein interactions at the promoter, and does not take enzymatic interactions into account

My view: under-construction